I'm not a doctor or researcher, but i have experimented on myself. For science right? 😁 A few drops of Lugol's iodine 5% solution in my drinks helped me a lot with being tired a lot and cold weather doesn't bother me like it did. I took NAC in mega doses during covid. It did something to my perception, well no more brain fog. Magnesium L-threonate helped me a lot with deeper sleep. Chromium and vanadium helped control junk food cravings. Astaxanthin is the latest one I've tried and it just keeps that healthy feeling going. Of course we need ALL essential nutrients and solitary or even multi supplements tend toward the "your missing this ONE (subset of) thing(s) " side of the unbalanced equation of panacea... The quick fix... In reality, it's all about maintenance intake of nutrients with occasional therapeutic dosing to correct properly diagnosed deficiency. Diet alone, may be insufficient to acquire ALL of the essential nutrients, but eating higher up on the food chain helps to mitigate the systemic risk of nutrient depletion in our soils and food supply. I've been thinking about trying shilajit for the fulvic acid, humic acid and trace mineral content.