What would your choice be for a desktop client (download or web-based) on a Mac? I've tried them all (I'm pretty sure) and still like Primal so far because it's fast and works for the most part.

I like Primal desktop enough, but it has its quirks

Examples

1) you can't just click the reply bubble icon in a note in the feed and start typing, you have to click through to the note and then reply

2) there's no way to submit via keyboard (i.e. TAB and then hit ENTER to submit your reply or note), you have to use the mouse and click the Post button.

Both of these slow down interaction