Diablo 2's Runewords are Being Resurrected in Diablo 4: Vessel of Hatred
During their livestream today, Blizzard announced a rather unexpected feature will be returning to Diablo 4 with Vessel of Hatred: Runewords.
https://www.ign.com/articles/diablo-2s-runewords-are-being-resurrected-in-diablo-4-vessel-of-hatred