Spike binds estrogen receptor and could alter collagenase gene expression

'My hypothesis is this (in the context of the modified mRNA-LNP products):

Since targeted delivery of the modified-spike-mRNA-LNP complex results in massive amounts of (intracellular) spike protein production, and spike protein binds to estrogen receptors, is it possible that this binding event prevents dimerization of ERs to subsequently down-regulate specific gene activity? And if so, is one of these genes collagenase? And if so, is this why we are seeing strange de novo connective tissue disorders and fibrosis in individuals post COVID-19 injection?'