It's always been known to be dangerous because of dual-use, ie. used for bioweapons research. If there is a great filter, I believe playing god is one of them.
"The National Academies of Sciences, Engineering, and Medicine (NASEM) released a report titled Biodefense in the Age of Synthetic Biology in 2018. Beyond focusing on pathogens and biochemicals, this report discussed how nefarious actors may use technical advances in delivering genetic information like messenger RNA (mRNA) to generate a new class of biological weapons: weapons that modify human cell protein expression. In the case of weaponizing mRNA, the report concluded that there are significant challenges “to determining the right targets or edits, packaging the genetic cargo into viral vectors, and delivering it to appropriate host cells.”