nvidia has proprietary drivers. That may be a challange. But if you're not into gaming opensource nouveau is running just fine.

if you choose progressive distro like fedora (i run it for decades) you'll be fine even with the newest hw.

Without dualboot or virtualized windows forget about app compatibility. running things via wine is not for everyone and it usually sux hard. either they build for linux too or you need to use an alternative sw (and there is an alternative for almost everything).