I backed up, reinstalled, and restored my desktop in an attempt to get Qubes to cooperate with Signet. I learned that this didn't help.
I realized that i do have another computer that I could borrow, yank the disk and pop in a new one, install Qubes 4.2 and see if I can repro the problem there.
I expect I will not be able to repro it. If that turns out to be the case, then I guess I'll buy yet another motherboard and start all over again.
But I guess a new motherboard is a lot cheaper than a Framework Laptop, which is the type of project I'd be likely to want to support if I were buying a whole new machine.