Most people died at like the age of 25. So, I suppose you didn't even get a chance to develop any reactions. IMO we just consumer too much that the body say "nah, i'm done"

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Yeah, I can see that angle too. Some people can't seem to moderate their consumption of, well anything. I reckon all substances have a threshold of toxicity and there are probably varations in that threshold based on different physiologies. Finding balance in life is a bit of a journey.