Replying to Avatar Sedj

Results as of 6 months on low-carb/high-fat carnivore diet

I took blood tests at 1 month in, and now at 6 months in. Prior to starting carnivore, I was being treated for slightly elevated cholesterol with a statin (Crestor - rosuvastatin), and have always also had low HDL cholesterol counts. I was narrowly pre-diabetic (A1C at or above 5.7%, at its highest, 5.9%). My weight over the past 10 years has ranged from 255lbs to 310lbs. When I started this diet (and also quit nicotine within a couple weeks), I was pretty close 310 lbs, maybe a little heavier on a bad day. I've also had my gall bladder removed, 10+ years ago.

I stopped taking Crestor several months before starting this diet.

My LDL numbers while on the statin were 83 and 73 (2021 and 2022 tests). HDL was 33/32, on those tests, and triglycerides were 132 and 161. "Total" cholesterol was 139/129. These numbers were keeping the doctors happy, and my cholesterol was "under control". I don't really want to take maintenance medications at all. I'm trying to get to a place where I don't need any medications to live without being deemed high risk for heart disease, stroke, or other internal failure. It may be a bit of a pipe dream, thanks to hereditary high blood pressure.

But the research on cholesterol is, at best, contested. The science hasn't definitively said that having a high cholesterol count causes heart attack, stroke, atherosclerosis (artery hardening), or really much of anything. It has potentially shown some specific correlations, but not causation. Most of the cholesterol scare was based on a hypothesis that didn't end up proving out in studies, but once it had legs through the US FDA and American Heart Association, it refused to die, and now we have doctors trained on old bad science.

So, my numbers a month after going carnivore. anything other than meat, eggs, and dairy was avoided almost entirely. No vegetables aside from herbs, seasonings, or medicines - and these were used rarely and minimally. Mostly because I don't cook my own meals always; part of living in an active family. Cooking in butter, ghee, lard, occasionally crappy olive oil. Not eating expensive meats, either. Mostly stuff on sale at the supermarket. Plenty of sausage, cured meats, shrimp, even sometimes corned beef or baloney. I'm not a purist, but am slowly getting better at my selectivity when it comes to which meats I put in my mouth. Right now I am still a meat whore.

Yes, numbers. 1 month after, LDL was 193, HDL was 39, Triglycerides 160, "Total Cholesterol" 265. My doctor convinced me to be prescribed Crestor again. I never filled the prescription. A1C was 5.6%, technically no longer prediabetic. Glucose at 98. BUN at 24 (twice prior number). I don't think there were any other numbers that changed significantly from past tests, and nothing the doctor was concerned about. He was definitely flipping out about the cholesterol numbers, threatening me with imminent death. Fuck that, still living, and living well!

6 months after (two days ago), LDL was 196, HDL was 39, Triglycerides 170, "Total Cholesterol" 269. Dr still threatening my with imminent death if I didn't go back on a statin. Tried to recommend some plant based margarine substitute sludge, nope. Red yeast rice? nope. It contains the same active ingredient as the statin, but in uncertain quantities. CoQ10? Funny, this one. the best way to get CoQ10 is through MEAT! Organ meat and reindeer meat are the highest, but beef is way better than pork or chicken. I don't fault him for this, he was trying to do exactly what his training told him, and what any medical standards board would expect of him.

I asked for a cholesterol particle size test in our next round of bloodwork, scheduled in 6 months. I'd even done enough research to know the name of the test from the testing service he uses. I will take that test in March. The doc told me that he didn't believe the results of that test would convince him that the cholesterol was not an imminent problem or change his desire to see my numbers reduced, but he also said that he would need to do a little research to even interpret the full results of that test - so I find that a little helpful. I will definitely be doing that research!!!

One thing I did gather from the results - my numbers did not significantly change between 1 month and 6 months. This indicates relative stability, not something running out of control. HDL is still low, but better than it ever has been. We didn't even do the A1C test, but glucose was at 95, BUN at 22, slightly less than the previous test. I want to keep an eye on that BUN number, because I care about my liver and kidney function a lot.

I think the tests were largely as expected. I will happily update with more in 6 months. Happy to answer any questions about numbers, both the ones I shared and any others you may be curious about.

One thing to consider here. The science, the research - it has been done almost exclusively on people that do NOT eat my diet. If I were eating standard American foods, even the "healthy" stuff, I would be 100% agreeing with my doctor that death is imminent and cholesterol needs to come down as soon as possible. I told my doctor this. The reality in my situation is that organs are functioning differently in response to being in ketosis, among other things, and not having to filter out all the toxins and garbage from plant foods. The walls of arteries and veins behave differently when insulin is reduced thanks to lower blood glucose. The efficiency of nutrient absorption is simply different. Having additional cholesterol in my blood does NOT necessarily mean it will create additional plaque on vascular walls. Some of this has also has to do with the particle size of that additional cholesterol.

I know that I will never return to a vegetable and sugar-heavy diet. I may have a sweet dessert occasionally, or have some sauces or other things that I know are not healthy. I may have a glass of bourbon, or worse, rum. Maybe a beer, among friends. However, I will probably never eat another bowl of pasta, rice, or salad. I doubt I will ever eat chips, crisps, fries, or most other potato foods again; if so, very sparingly or incidentally (like my mother in law makes this really good tuna casserole, and uses potato chips to "crust" the top of it. I may have a small portion, just because I really do like the taste, and out of general politeness). This is much different to me than eating a bag of chips. Yes, there are noodles as well, and that is why I would only have a very small portion, not a big bowl or mound on my plate.

Nothing in the last 6 months, including these test results, is convincing me of any need for plants in my normal diet. I don't need fiber to take a shit, or do anything else for that matter. Fiber continually scratches the walls of the intestines, making them slimy with a similar substance to what forms as part of a scab before the scab hardens. This lubricates the intestine making waste that is difficult to pass slide through easier. Well, my waste is much less than normal (normally only need to shit every 3-4 days), and is (actually thanks partially to not having a gall bladder) already more liquid and more comprised of oils and fats, so it is self-lubricating. I don't need scratched up intestines being at risk for inflammation or infection. Because of this major change, as well as differences in where digestion is actually occurring in my system when it comes to digesting meats versus plants, and where stomach acids, bile, etc. are actually concentrated, I think I am likely at far less risk for intestinal and colorectal complications, cancers, etc. I did have a prostate screening blood test and showed no markers for that.

Yes, this was a long read, but with lots of information. Please don't take my word for any of this; these are my best guesses and assumptions based on my own research, which was far from exhaustive. Do your own research, and if it directly contradicts what I am saying, let me know.

Sedj, two things that popped in my head: 1) if you are an undermethylator (ie have an mthfr mutation) this will fuck up cholesterol (your always low hdl lead me to this, also saw no mention of homocysteine but a high homocysteine would point to this too) and 2) thyroid hormone is essential in cholesterol processing and your gall bladder removal points to a thyroid issue to me. T4 is what pumps the gall bladder, if you lack sufficient T4 then the gall bladder slows and sludge forms and then docs suggest removal instead of giving the thyroid some love. Low levels of thyroid hormone also create an increase in cholesterol. Make sure your TSH is 1.8 - 3.0. This is optimal range. If not, then maybe focus more on thyroid and liver for a bit. Selenium and iodine will support thyroid. Might need some fiber for the liver to do its job well...even just psyllium husk. Just thoughts, obvs im not a professional of any sort. 💜

Overall, awesome work and thanks for the update! 🤙

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My always low HDL definitely points to some things. It had been 31 for a while, and in my 30s dropped to 26. Crestor and at least trying to be healthier got it to 32/33. (not really crediting Crestor here, but that was a factor at the time). Now carnivore got me to 39. That tells me I'm on the right track. I will be exploring more ways to raise my HDL number.

I've been tested for thyroid issues before, and had some family history of it. Tests did not show any abnormality. TSH with reflex to FT4 was 2.13, 5 months ago.

def right track 🚀 tsh is perf ✨ interested to know what else you find for the hdl 🙏