Nah. 1kg × c² = 9×10¹⁶ Joules.

The largest nuclear weapon ever tested was the Tsar Bomba, at 50megatons of TNT equivalent. That works out to 2.1×10¹⁷ Joules, a bit over twice as much energy (it weighed 27,000kg, so only a small fraction of its mass was turned into energy).

The Tsar Bomba only managed to produce a fire all 8km in diameter. That's _so_ many orders of magnitude away from wiping out all life.