It’s possible. Basically the same thing but a bit more complicated. You do lose some of the security properties though with groups.

But that’s the same with telegram, signal and all the others too.

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https://mov.im already has it and it's opensource.

It would be nice adding Nostr to this list https://omemo.top

What security is lost by using OMEMO exactly?

Nostr isn’t XMPP.

Neither is irssi (it's IRC, yet it supports OMEMO encryption).

OMEMO is an encryption protocol, not a messaging protocol.