Wow! No genetic change in millions of years? How is this possible?
Discussion
That is a great question.
So,here is what I found out from the National Geographic.
These fish are 'living fossils'âamong the most primitive animals on Earth
For 150 million years, garsâa group commonly derided as âtrash fishââhave mostly stayed the same, a rare consistency not even seen in sharks, a new study says.
ByJason Bittel
March 28, 2024
If you could hop into a time machine and travel back 150 million years, the world would have looked very different. The supercontinent known as Pangaea was just beginning to break up, stegosaurs plodded across the land, and ichthyosaurs plied the seas.
But if you stuck your head into a stream, you might have spotted a familiar face.
Known as âliving fossils,â gars are a group of toothy, torpedo-shaped fish that have remained relatively unchanged across vast expanses of time. Ancient gar fossils show a surprising number of similarities to the seven gar species alive today.
Of course, many species meet the criteria of âliving fossilâ since Charles Darwin first coined the term in 1859. (Read more: âThese 5 âliving fossilsâ still roam the Earth.â)
But now, a new study shows that, at the molecular level, gars are the most living fossil-y of all living fossils. And itâs not even close.
A gar with baige,silver, and black scales in a brick like pattern and a flat and long mouth.
The largest of seven known gar species, alligator gars (pictured, an animal in an aquarium) have a torpedo-shaped body and razor-sharp teeth.
Photograph By Solomon David
Of 481 vertebrate species, the researchersâled by Chase Brownstein and Thomas Near of Yale University and Dan MacGuigan of the University of Buffaloâfound that gars have the slowest rate of molecular evolution known to science.
Even across millions of years, their DNA and RNA have changed up to three orders of magnitude more slowly than any other major group of vertebrates, including other classic living fossils such as coelacanths and sharks, says Solomon David, an aquatic ecologist at the University of Minnesota and co-author of the study, published recently in the journal Evolution.
The scientists believe the garsâ sluggish evolution may be due to an over-active DNA repair mechanismâa genetic quirk that could lead to advances in human medicine.
Slow evolution, âextraordinaryâ hybrids
To arrive at these conclusions, the authors first had to assemble an extensive family tree of species with published genomes.
Then, by zeroing in upon exons, or coding regions of DNA for all the species within that tree, they were able to estimate the rate at which a given species changed over evolutionary time.
They discovered that placental mammals, such as humans, had mutation rates of about 0.02 mutations per million years, whereas amphibians evolved much more slowly at a rate of 0.007 mutations per million years.
But gars? They averaged only 0.00009 mutations per million years at each exon site.
The study authors also report a related discovery: Gars are the most distantly diverged organisms known to hybridizeâa record previously held by two species of ferns separated by some 60 million years.
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For instance, alligator gar and longnose gar, whose territories overlap in the southern United States, last shared a common ancestor a hundred million years ago, but the species can still interbreed. Whatâs more, their hybridized offspring are fertile, says David. (Read more: âLigers, zorses, and pizzlies: How animals hybrids happen.â)
A hybrid alligator gar on a black background.
Alligator gar and longnose gar, whose territories overlap in the southern United States, can hybridize, as seen in this animal above.
Photograph By Solomon David
Interestingly, alligator and longnose gar hybridization isnât some hypothetical experiment. Earlier this month, Kati Wright, a masterâs student at Nicholls State University in Louisiana, hauled a six-foot, alligator-longnose hybrid out of the Trinity River in Texas, an extremely rare find.
âWhen you look at their snout, itâs obvious,â says Wright, explaining the hybridâs nose is wider than that of a longnose gar but not as wide as an alligatorâs.
It may be that the gar familyâs extremely slow evolutionary trajectory is what allows these distantly related cousins to continue producing offspring, since their molecular makeup is so similar, David suggests.
Carl Rothfels, an evolutionary biologist at Utah State University who discovered the hybridization between ferns and was not involved in the new study, says the level of hybridization shown in the new study is even more extreme than a human and a lemur producing fertile offspring.
It's "extraordinary,â says Rothfels, who was not involved in the research, in an email. âOff the charts!â
Help for humans?
Aside from setting new records all over the place, the scientists believe that the garsâ evolutionary secrets, such as their efficient DNA-repair mechanism, could benefit human healthÂ.
âAs you copy DNA over and over and over again, you can get mistakes or changes,â says David. âBut gars have something in there that when a mutation pops up, it gets corrected.â
David likens the process like a game of telephone that plays out over the millennia. When most organisms play it, the phrase whispered at the beginning changes over time until it takes on a totally different character by the end. But when gar play, the phrase remains nearly the same.
âIf we can isolate what that isâand weâve got some ideas as to what gene that might beâwe can then take it to the next step of thinking about implications for human medicine and disease,â says David, who already breeds gar for use as model organisms.
For instance, if whatever is correcting those mutations can be replicated in human bodies, it could potentially prevent or counteract diseases such as cancer, the result of shortcomings in DNA repair and cell growth run amok.
If it all works out, there would be a delicious bit of irony for David, who spends a lot of time trying to change minds about fish that have long been persecuted for being ugly and of no commercial value.
âThese fish that have been mistreated and considered âtrash fish,ââ he says, âmay end up turning around and actually being extremely valuable to us from a human health perspective.â
So faulty or inefficient DNA repair mechanics are what allow genetic change/drift to happen? Is there a limit to how much change can happen?
This is way beyond my knowledge of the matter. So, I went and asked Venice.AI. This is what came backnas an answer:
There is no strict limit to the amount of change that can occur in a species' DNA over millions of years. In fact, over very long time scales, the DNA of even long-established species can change quite a bit. However, there are several factors that can limit the rate of change and the types of changes that occur:
1. Mutation rates are finite. While mutations occur randomly at a steady rate, there's an upper limit to how many mutations can happen over any given time period. This means the DNA of any species will only accumulate so many mutations per million years.
2. Most mutations are deleterious. The vast majority of mutations reduce the fitness of an organism and are quickly purged from populations by natural selection. This means only a small subset of mutations can become fixed in a species over millions of years.
3. Genetic drift is a random process. In small populations, random chance (genetic drift) can occasionally fix some neutral or beneficial mutations. But in most species, populations are large enough that genetic drift has a limited impact.
4. Adaptive zones are constrained. The DNA of any species is limited by the "adaptive zone" it occupies - the range of environments and ecological niches it can survive in. Only certain types of mutations will allow a species to expand its adaptive zone. So even if it evolves a lot, a species is still limited by the potential for further adaptive evolution.
So in summary, while there's no strict limit, a combination of factors including mutation rates, the effects of selection, genetic drift in small populations, and constraints on adaptive zones, can all limit the amount and types of changes that occur in the DNA of a species over millions of years. But in theory, with enough time, a species' DNA could diverge quite dramatically from its starting point.

