Arch is what I typically run, and learning Qubes helped me understand the relationships between each distro, the file compartmentalization was enjoyable to use. I haven't gotten into nix
I've stopped using it as my daily driver. I found version upgrades required quite an investment in time and their perfered approach to declarative config kind of sucks. I now use nixos and i try and compartmentalise as much as possible. https://github.com/CertainLach/nixos-qubes looked really promising and it looked like they were making a lot of progress really quickly but they seem to have abandoned the project 9 months ago.
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