The prohibition had a horrible effect on the game of genetic selection played by the growers. Some qualities of the plant got pushed forward and others minimized. There is now a movement to try to go back and recover some of the strains (or at least their qualities) that were kind of removed from the pool as grower wanted to avoid certains smells and increase the mental high at the detriment of beneficial qualities (anti inflammation being a big one, too much CBD cancels THC high)

Now we have a whole lot of freaks (too much THC in the ratio, or too much CBD (headaches)). Also, the other cannabinoids have not been considered while they were crossing the strains. THC V (I think) helps with insuline problems, CBD N helps with sleep, and so on.

Last but not least, terpenes seem to have a modulating factor on the canabinoids. Free the plant, free the research.