I'm using Flycat and Amethyst mostly, but it's not as big of a deal for me here on Nostr, could achieve (and somewhat have already) something similar by following hashtags and actively maintaining my block list.
Discussion
I’m surprised that nostr:npub1gcxzte5zlkncx26j68ez60fzkvtkm9e0vrwdcvsjakxf9mu9qewqlfnj5z hasn’t added a keyword mute list! Amethyst is so packed with features already!
Working on other stuff, like private DMs, local database, etc.