4.2 introduced pipewire, but it's not officially supported in dom0
https://github.com/qubesos/qubes-issues/issues/6358#issuecomment-1712130215
some have reported a temporary fix
https://forum.qubes-os.org/t/4-2-sound-issue-and-temporary-fix/23095
but check this out before you go removing pipewire
https://forum.qubes-os.org/t/v4-2-pipewire-installation/19140
unfortunately i'm super busy atm and can't speak to your specific issue/hardware, but check this out as well
lmk how you go