I know it's just a meme, but...
Adopting the Constitution itself was giving up some rights, to appease the crybaby liberals of the day. What do you call "eminent domain"? That was giving the "government" the right to take your private property. People yielded up the right to decide how to live their own lives in some matters to a group of people called their "representatives" who actually don't represent them. The "Antifederalists", like Patrick Henry, saw through this, and opposed adoption of the Constitution, because they foresaw that by adopting it, the liberty they had won in the War for Independence was now being thrown away...