They are number 2. Number 1 is a drug called Humira, which is a "miracle drug" used for treating autoimmune diseases, especially rheumatoid arthritis.

Look up the incidence rate of autoimmune disease on a historical chart btw. Everyone is bloody sick these days with one of these.

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This is what I found

Yup, that's pretty much accurate. 1-2% of ALL women now have Hashimoto disease. If our hunter gatherers were as sick as we are today, we would have gone extinct a long time ago.