thats an excellent question and while I Havent seen research on that directly, I will hypothetically guess yes bc higher T is systemic and that's the reason for the increased tolerance so im guessing it affects all epithelial cells similarly. however, on a zoomed in view, individual guts can have weaknesses due to poor diet or low enzymes to break down food etc and that may lend to more sensitivity on the way out. your colon will def let you know what it needs 😆