The UI is all JS no matter what. Best to use web standards and avoid all frameworks and build tools. We don't need them.

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That depends on what general purpose language you want to use for your backend though. Go is much more perfomant than JS, it's strongly typed and compiled. Development is much better than JS or Python

I’m only talking about the UI where a toolchain and build step is unnecessary

Oh yes for sure, although css has become pro damn powerful recently