Yes but there is no one database and every client is built different. Just because there are 20 clients doesn't mean you have to use all of them. I have stuck with one client and i have never lost my follows list or relay list like others
The fact that you have been stuct with one client doesn't mean it is the reason why you haven't lost any follows yet. 😉
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Ive used all clients just not with my nsec. I generate new ones.