Qubes is great for isolation of malicious code for threat hunting. Most people get hung up on the networking/usb and copy/paste between VMs. I use Proxmox similar to Qubes.
Discussion
Tested Proxmox a decade ago, can it be used the same way?
The really useful thing is building good habits that separate things up well, anything that can do that well is worth trying out as I see it :-)
It has come a long way in decade. Can run VMs or LXC with SDN vlans and full network stacks. I run a full home cyber range network on it. Can split up vGPUs or passthrough hardware. Not so much desktop but I use mostly cli.
Yeah anything is possible in command line only hehe :-)
But for general, daily use then running all and any VMs in ONE screen only, seamlessly is pure genius