It’s a big question and I think it will be tough for many to know what to do with astronomical gains and how to hodl when the number is huge. If you believe in Bitcoin it doesn’t make sense to cash out for USD at some lofty valuation. Then you’re just stuck with a currency that is going in the wrong direction and have no Bitcoin to show for your efforts. I suspect the gains will be too good for many to ignore though. I do think that trimming some BTC to pay off debt or buy a house outright as you said are good ideas, and a Bitcoin-focused business is an excellent idea. It will no doubt vary for everyone but improving one’s life (and helping others), freedom, independence, life experiences are always worthy goals.
-Tom