Notifications might be a big thing. A lot of time I don't even see someone reacted to my posts and at the same time there is purple dot indication on notifications when there is nothing new showing in the tab.
It is easy to miss posts by people i'm following. Something like lists or multiple feeds (for different themes, groups...) would help a lot.
Both these issues mean I don't see things I'd react to, in some cases even leading tothe other side feeling like I'm ignoring them. This is crucial esp. for new users imo.
I have to manually go to each users profiles to see if there is something I missed.
Yes I'm following 1000 npubs so my feed gets similar to global at times. But even that can be not that busy at times and I still miss some notes from people I'm following because of timing mismatch (they post at different time than when I'm looking at my feed).
Hope this helps. Thanks for your hard work 👍.