This has already been accomplished by using Alpha-gal as a vaccine adjuvant

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What did they do to make everyone lactose intolerant? And why is that such a thing now?

That has two causes that I am aware of. First, some people are genuinely lactose intolerant due to a gene variant in some ethinic groups. Second, pastuerization. The heat destroys lactase, the enzyme that the body uses to help digest dairy.