Fedora or Debian, because Qubes uses them.

(Not recommending Qubes, because it's low performance for high security, and a part time job to run, for which you won't be paid money.🤕)

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Would Qubes be a good option for a secure server?

That's rather a question whether a VM would be a secure server.

That's what Qubes is - a server of Fedora and Debian VMs.

Professional VM servers use other VM setups - not Qubes.