Likelihood depends on rate of growth. Atm I don't believe it will be a problem. Especially with future Seraphis modularity and efficiency upgrades. I'm running a node right now 150ish GB.
Aeon (not a maxi of either, user of both) would be a great person to give you a better high quality answer to this type of question. I believe he is going to present at Monerotopia in May: https://twitter.com/aeonbtc
#[12]
But for now I leave you with this to chew over:
https://sethforprivacy.com/posts/dispelling-monero-fud/#monero-cant-scale
https://sethforprivacy.com/posts/comparing-private-spends/#results