Protein C is a protein that plays a crucial role in regulating blood clotting and preventing the formation of blood clots, particularly in the veins. It works by inactivating clotting factors V and VIII, helping to prevent excessive clotting. A deficiency in protein C can increase the risk of blood clots, leading to conditions like deep vein thrombosis (DVT) and pulmonary embolism.

Key Functions of Protein C:

Anticoagulation:

Protein C, in its active form (activated protein C or APC), acts as an anticoagulant by inactivating clotting factors V and VIII.

Regulation of Blood Clotting:

It helps maintain the balance of the blood clotting system, preventing excessive clotting and potentially dangerous blood clots.

Protection from Thrombosis:

A deficiency in protein C can lead to an increased risk of thrombotic events, such as DVT and pulmonary embolism.

Maintenance of Vascular Permeability:

Protein C also plays a role in maintaining the integrity of blood vessel walls.