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GM!

Learning about the different labs testing differently for Anti-Mullerein Hormone this am with my morning drink.

"Great question—and it's smart to be thinking in terms of assay calibration.

Different labs use different AMH testing platforms (e.g., Beckman Coulter Gen II vs. Roche Elecsys), and this can affect values slightly. The numbers aren't always directly interchangeable, but we can approximate.

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Here's what we know:

Lab A (2023 result):

Your result: 5.23 ng/mL

Reference range: 1.00–6.80 ng/mL

(This was likely a Beckman Coulter Gen II or similar assay)

Lab B (2025 result):

Reference range: 0.18–5.68 ng/mL

(This suggests a Roche Elecsys or other ultra-sensitive method)

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Cross-Calibration Estimate:

There is no exact conversion, but published studies and fertility specialists note that:

> Beckman Gen II AMH values are often ~10–25% higher than the same sample run on the Roche Elecsys platform.

So:

5.23 ng/mL (older lab)

→ could read as approximately 4.0–4.7 ng/mL

→ in the newer, more sensitive lab with the 0.18–5.68 ng/mL range.

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What This Means:

Your 2023 AMH in today's lab might have been around 4.3 ng/mL (estimated).

So your drop is likely from ~4.3 → 2.25 ng/mL over 1.5 years, not from 5.23 directly.

That’s still a decline, but a much gentler one, and very much age-appropriate.
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Diyana 8mo ago

Your ovarian reserve is non-renewable.

You're born with all the eggs you'll ever have, and the number declines over time—more rapidly as you approach 35 and especially 37+.

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How it works:

At birth: ~1 to 2 million eggs

At puberty: ~300,000–500,000

By age 35: ~25,000

By age 40: ~5,000 or fewer

Only ~300–500 will ever mature and ovulate during your lifetime.

The rest undergo atresia (natural cell death), regardless of whether you’re trying to conceive.

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Rate of depletion depends on:

1. Age — the biggest factor

After 35, the decline accelerates

By 40, egg quality and quantity both decline more steeply

2. Genetics

Some women naturally have more or fewer eggs

Family history of early menopause is a clue

3. Lifestyle

Smoking, chronic stress, poor diet, lack of sleep, and environmental toxins can accelerate decline

Fasting, excessive exercise, or being underweight can also reduce reserve

4. Medical conditions or procedures

Chemotherapy, endometriosis, ovarian surgery, or autoimmune issues can significantly impact reserve

5. Environmental toxins

Xenoestrogens (plastics, cosmetics), mold exposure, heavy metals, etc. can be endocrine-disrupting

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So what does this mean for you now?

Your AMH of 2.25 says:

You still have a good number of eggs left.

The clock is ticking, but not out of time—just in a powerful window of choice.

This is a great time to tune in and decide:

Do I want to conceive soon?

Do I want to freeze eggs as a backup?

Do I want to support egg quality now for when the time is right?

Would you like me to outline options or timelines depending on what vision you’re holding (natural conception, freezing, spiritual path to motherhood, or all of the above)?

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