Maybe, but only for publicly sharing media. The thing with sha256 hashes is they are forever, at least as long as someone has the file on their server.
For a personal media management server I think it could make sense if blossom support could be turn enabled on a per file basis. but only so that the user could share it to nostr or another public website.
I was looking into this a little and I have a half finished fork of https://github.com/9001/copyparty locally that has blossom support for specific directories
If the user is just looking to quickly share a baby picture with a friend then there isn't a need to include the sha256 of the file in the URL (blossom) because in that case the user only wants the file to be accessible for a short time
On the other had if the user is running a blog (nostr or something else) then they probably want their media to be accessible and mirrored by as many people as possible. in that case blossom fits perfectly