In most clients I use you can but sometimes it doesn't work so well. I have some accounts I mute but it seems they get around that by refollowing me but I'm not sure.

nostr:nprofile1qyxhwumn8ghj7e3h0ghxjme0qyd8wumn8ghj7urewfsk66ty9enxjct5dfskvtnrdakj7qg4waehxw309aex2mrp0yhxgctdw4eju6t09uq3wamnwvaz7tmjv4kxz7fwwpexjmtpdshxuet59uqzp75cf0tahv5z7plpdeaws7ex52nmnwgtwfr2g3m37r844evqrr6jh8rnkd might me a better person to ask.