January 17 – Florentine explorer Giovanni da Verrazzano, on board La Dauphine in the service of Francis I of France, sets out from Madeira for the New World, to seek out a western sea route to the Pacific Ocean.

March 21 – da Verrazzano's expedition makes landfall at Cape Fear at what is later the U.S. state of North Carolina.

April 17 – Verrazzano's expedition makes the first European entry into New York Bay, and sights the island of Manhattan.

July 8 – Verrazzano's expedition returns to Dieppe.

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