It would disable only in that client. And you can't prevent someone from publishing on Nostr, of course, so the comments would still arrive; they'd just include people complaining that the button for replies is missing.
Jumble has the "hide untrusted replies" feature, that allows you to simply not see anyone you don't want to see. Or, you just set your inboxes to something like a personal relay. Then you would see comments only from there.