Yes, and no.
If you have a btc backed loan, your collateral (btc) accrue interest, because you never sold. And if btc raises more, than your interest, you won.
Actually this is how the rich lives.
Buy, borrow, die.
They buy investments, and take up loan, that costs less, then their gains.
But you have to be careful, not to get liquidated.
Also there is a type of loan, that has no monthly payment.