You would know when it were obvious people who took it fared better than those who didn’t. It’s a high bar to clear, but it should be high.

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Having worked in that field, fwiw, it is shockingly difficult to attribute causality to any changes you see. Even if done in good faith you usually need really large trial cohorts to know if people are "faring better" because of an intervention.

Plus placebo and nocebo are really real..

I think it would be obvious if people with cancer were getting cured via mRNA (which I doubt would happen). But if it did, people would notice.