I would say Qubes is a better OS than TAILS for compartmentalization and isolation. Disposable VMs can accomplish the amnesiac part of TAILS

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I love qubes and use it as my daily driver but read their documentation. Even the disposable qubes are not 100% amnesiac, some bits do run outside of RAM and does leave traces. This might be OK for nym but if full Nemo is required stick to tails.