Hassouna and ten relatives including her pregnant sister were killed when an Israeli missile struck their family home in Gaza City's Al-Touffah neighborhood on 16 April 2025.

The attack occurred one day after her documentary's selection for Cannes was announced.

She had previously written on social media "If I die, I want a loud death".

Hassouna was one of at least 175 journalists killed in Gaza, Lebanon and Israel by April 2025 according to press freedom groups.

An investigation by UK research group Forensic Architecture concluded Hassouna's death was the result of a targeted attack – the missiles dropped by the Israeli military had "specifically targeted the Hassona family’s apartment on Floor 2" of the five-floor building.

The Israel Defense Forces stated they targeted "a Hamas member involved in attacks against Israeli soldiers", claiming use of precision weapons.

Sepideh Farsi rejected this justification, stating: "I know the whole family. It's nonsense".