I have an opinion about nicotine too. I have smoked cigarettes, menthol Camels, chewed Copenhagen, smoked cigars etc. I still smoke cigars when I want to. Cigarettes are addictive, but not as a result of bioactive nicotine. If that were the case, tobacco would cause the same response, and it doesn’t. I think the use of tobacco started as a result of its effectiveness at preventing the transmission of mucosa dependent viral respiratory illness. I don’t know what big tobacco has done to add addictiveness to tobacco products, maybe ask the soda companies, but I assure you, it isn’t tobacco or nicotine itself.
Discussion
No need to theorise on this.
Nicotinic receptors (nAChRs) regulate inflammation and expression of ACE2 receptors. Saturate the receptors using nicotine (or things like Vitamin D which has an affinity for ACE2 expression) and you have an effective prophylactic.
It has been my experience.
interesting because vitamin D is great for skin health in other ways too, and nicotine lowers surface circulation which tends to lead to clogged capillaries and poor skin condition. my primary dietary staple is milk and it's loaded with vitamin D, and my skin looks better than it has in years... and I'm managing to easily stay away from restarting the nicotine intake.
i had an unusual motivation though - severe allergies that seem to primarily come from seeds or seed fed animal products. hard to smoke when you are wheezing. plus, for me, the smoking was really just a cover for a chronic hypocapnia problem caused by seed allergy.
They mention pyrazine in the video as the addictive additive
Lots of addictiveness of cigarettes etc comes from the sensory touch on the libs. It's something positive related from earliest childhood.
At least that is something a woman working with drug addicts once told me..
Much of the addictiveness is from psychological conditioning from decades of public relations campaigns and marketing, the memes that go around these sayings people have.
The suppression of hypocapnia is a very relevant one though. This is something you don't get with vapes. Hypocapnia is something that often is associated with asthma and it causes you to need to breathe more even though you have enough oxygen - because you breathe too fast, you reduce the CO2 level and that reduces the capacity of haemoglobin to release oxygen into cells, CO2 unlocks the cage that the iron based protein holds oxygen with.
Also, nicotine is likely not too far distantly related to caffeine and theobromine and theobromine in particular increases breathing efficiency.
This reminds me of the nose breathing athletic technique used to maintain blood CO2 levels. Strange that a waste product would be so integral to our health eh?
nature tends to find a use for everything eventually. I'd guess this one dates back to the inception of cardiovascular circulation for larger animals that have a vast distance between the input and consumption of resources. By vast, I mean centimetres or more. Worms and slugs don't have a vascular system, and most small creatures like them rely entirely on motion and osmosis.