Might not be the delivery vehicle that's as damaging as much as the spike protein the body's cells are instructed to produce, which is highly cytotoxic. The fact that LNPs can cross the blood brain barrier is a feature in cancer treatment, but a bug when its producing a toxic protein that has no business being in blood stream, lymph nodes and organs. If it too concentrated ie. Accidentally Injected intravenously (happens ca 1% of the time), it can damage the endothelium because the T cells will kill the cells expressing the spike. Bolus theory.
Always nice to discuss these topics.
About the amyloidosis patients, they used to be terminal patients, but with partisiran they are not terminal anymore!
They are taking LNPs every 2 weeks for the rest of their lives, the oldest of them since 2015 (https://clinicaltrials.gov/ct2/show/NCT02510261 - it took 3 years more to approve it). So it's not a single shot once in a while, it's a very suitable cohort to test chronic exposition to those molecules. Under that clear evidence and weighting the risks and benefits of its mass administration, the decision was made.
My point is, where is the new evidence (after 2018) that supports all the conspiracy theories going around?
(Just as a note apart, testing exact molecular compounds for decades before approving them is just unrealistic, that's why phase 3 and phase 4 was delineated...
Another note: on clinical trials, terminal patient = ok give whatever, is an over simplification of how the real process is going on. Terminal patients are still humans, they are on a very vulnerable position and there are still many regulations that must be met, this is more of a bioethics topic...)
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