The biggest trade off might be fewer opportunities. It’s still difficult at times to interact with the legacy way of thinking. Some people just don’t understand it and refuse to even consider working that way. They are born into a society that operates with in-person on demand cooperation and it’s super hard to get them to think in different ways. Some people just don’t like it and prefer to be face to face or sync up often.
It can get uncomfortable to explain to someone and at that point the opportunity is already lost.