Competitive leagues have all kinds of criteria for entry and classification. Some leagues have criteria forbidding the presence of some chemicals (like steroids). Some leagues have age-based or bodyweight-based criteria, etc.

One could imagine a league having a rule such as “contestant must exhibit cells which replicate exactly two X chromosomes” or “contestant must exhibit cells which replicate any number of X chromosomes but no Y chromosomes”.

Historically, leagues seem to have lacked such specificity. If there’s demand for leagues with such specific criteria, then it sounds to me like an opportunity for entrepreneurship.