I have been testing and using SimpleX for over a year now. I have had many conversations with Evgeny and it has been amazing to see how far it has come. I posted the podcast someone linked to this chat. It's highly technical but so worth it and you should definitely see why I say ilthe develooment is in good hands. Evgeny even discusses it's current shortcomings and that is so refreshing.
I recommend both SimpleX (and Briar), they both have PFS. Adoption is important for privacy and security. IMO Signal/Molly (Hardened fork of Signsl) has more users and is easy to use so it's good for day to day e2ee communication and normie adoption while SimpleX and Briar are for more specialized use cases.
Both SimpleX and Briar have been successfully audited. SimpleX is my recommended go-to for private anonymous communication. SimpleX is well on its way to being a Matrix killer IMO (which I also still currently recommend for business use) then possibly a Signal killer.
0xchat looks cool but is not as robust in it's design or encryption as SimpleX and it has not been audited so it currently does nit pass our strict guidelines for recommendation.