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Paul Graham / @paulg (RSS Feed)
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San Francisco is going to bounce back amazingly once they get rid of the tiny cabal of corrupt and incompetent politicians who are dragging it down.

https://nitter.moomoo.me/paulg/status/1687254959522467843#m

**RT @garrytan:**

Cedana (YC S23) lets you save, load, and migrate any compute workload. Meta and Alphabet had this years ago, but now anyone has access to this.

For AI inference this is a godsend: Cedana enables ChatGPT-fast latency while boosting GPU utilization 5x

ycombinator.com/launches/JAP… (https://www.ycombinator.com/launches/JAP-cedana-real-time-compute-migration)

https://nitter.moomoo.me/pic/card_img%2F1687126641577766912%2Ft6fdb4Gv%3Fformat%3Dpng%26name%3D800x419

https://nitter.moomoo.me/garrytan/status/1687199533275725824#m

Alarming to think that this engraving of Henry VIII was not meant as a caricature.

https://nitter.moomoo.me/paulg/status/1687153970744344576#m

**RT @FitFounder:**

An 80 year old man who lifts is as strong as a 30 year old man who doesn't.

After the age of 30 muscle mass decreases by approximately 3-8% every decade. This rate of decline becomes even faster after the age of 60.

This reminds me of my dad who decided to start lifting &…

https://nitter.moomoo.me/FitFounder/status/1687116072586211328#m

**RT @Austen:**

Zuck is only a sweetheart today because it’s no longer convenient for him to be the evil billionaire scapegoat.

As soon as it’s convenient to blame an election or war or whatever on him the thinkpieces on how evil he is will magically start showing up again.

nitter.moomoo.me/CGarrett\_15/status/1686907972252041217#m (https://nitter.moomoo.me/CGarrett_15/status/1686907972252041217#m)

https://nitter.moomoo.me/Austen/status/1686999266827661312#m

Since everyone doing AI is constrained by lack of GPUs, the current state of the art in AI is actually significantly better than it appears to be.

https://nitter.moomoo.me/paulg/status/1686988608274841600#m

Talked to some of the startups in the current YC batch. There are a huge number of AI startups, but not one I talked to seemed bogus. There are that many legit opportunities in AI.

https://nitter.moomoo.me/paulg/status/1686983163627847680#m

**RT @gigaj0ule:**

Small molecule oral cancer drug kills 100% of solid tumors across 70 evaluated cancer types in vitro and in animal models with a therapeutic index of 6 and no discernible side effects

Phase 1 trials now underway

cell.com/cell-chemical-biolo… (https://www.cell.com/cell-chemical-biology/pdfExtended/S2451-9456(23)00221-0)

https://nitter.moomoo.me/gigaj0ule/status/1686814611658715136#m

"Throughout the event, various young people bobbed up and down to denounce me, mostly for things I hadn’t ever said or written and didn’t believe."

That's the thing that will probably surprise you most if you become well enough known to attract haters.

unherd.com/2023/06/the-oxfor… (https://unherd.com/2023/06/the-oxford-kids-are-alright/)

https://nitter.moomoo.me/pic/card_img%2F1664046702200799234%2Fw0m8UE5-%3Fformat%3Djpg%26name%3D800x419

https://nitter.moomoo.me/paulg/status/1664229657162424320#m

There were 18,538 gunshots in a 77 block area of St. Louis between 2014 and 2018. That's 48 gunshots per block per year. Almost one a week.

nitter.moomoo.me/lefineder/status/1662908824972304385#m (https://nitter.moomoo.me/lefineder/status/1662908824972304385#m)

https://nitter.moomoo.me/paulg/status/1663205740696289280#m

18 hours into visiting NYC and 11 yo has already eaten three giant pretzels. He says the one from Schaller & Weber is the best so far.

https://nitter.moomoo.me/paulg/status/1663198911157116933#m

"This is a trend I’ve noticed with other students and also with editors at publishing houses: whether their work will be condemned for sexism, racism, cultural appropriation and so on. This is the contemporary anxiety for young writers today."

nitter.moomoo.me/Hanifkureishi/status/1660315891488227331#m (https://nitter.moomoo.me/Hanifkureishi/status/1660315891488227331#m)

https://nitter.moomoo.me/paulg/status/1662595313142571008#m

When young founders build something that they don't want themselves but that they believe some group of other people want, 90% of the time they're building something no one wants.

https://nitter.moomoo.me/paulg/status/1662483849203314695#m

Good axioms are unfalsifiable. If you choose falsifiable statements as axioms, all your conclusions will be warped by the need to avoid acknowledging evidence that they're false.

https://nitter.moomoo.me/paulg/status/1662408333846872064#m

**RT @Suhail:**

Startups are mostly about determination I find. For a little while you might overlap a lot with another company but over time opportunists flame out and all that’s left is you or you stick to your users and adapt to a clearer direction. It’s helpful to believe in something though.

https://nitter.moomoo.me/Suhail/status/1662284264132722691#m

**RT @PaoloShirasi:**

Just-published study analyzed ancient human genomes to reconstruct human out-migration from Africa and finds a period of genetic adaptation within the last 45,000 years in non-African regions affecting various biological (including neurological) systems.

pnas.org/doi/10.1073/pnas.22… (https://www.pnas.org/doi/10.1073/pnas.2213061120#sec-6)

https://nitter.moomoo.me/pic/card_img%2F1661112832178397192%2FDAxVAI0P%3Fformat%3Djpg%26name%3D420x420_2

https://nitter.moomoo.me/PaoloShirasi/status/1662202408661811200#m

You can make a living without living somewhere expensive. This seems an important and probably permanent change.

nitter.moomoo.me/ModeledBehavior/status/1662091667971686401#m (https://nitter.moomoo.me/ModeledBehavior/status/1662091667971686401#m)

https://nitter.moomoo.me/paulg/status/1662134826483236864#m