There is an underappreciated link between fatty liver/NAFLD and gut inflammation/dysbiosis/hyperpermeability.
When the intestinal barrier breaks down, bacterial endotoxins enter the portal vein.
It drains directly into the liver, so hepatocytes are first exposed to things like LPS.
LPS triggers inflammation, ROS, and TNF-alpha release which impairs mitochondrial function.
Then there is also the bidirectional link between bileflow and dysbiosis.
Ethanol or acetaldehyde produced by certain microbes will overwhelm liver detox pathways.
Many people also have a high ammonia burden due to high urease activity in certain bacterial strains -> more pressure on the liver.
To the extent that dysbiosis impairs SCFA production, you get further metabolic dysfunction.
Gm
50-100mg per 10kg is a good amount
Excessive caffeine use will also deplete B1 status.
It reduces B1 absorption & increases B1 wasting at the kidney level.
Combine excessive coffee use at work with alcohol consumption after work for long periods of time and you can get into trouble.
Not to mention the synergistic requirements of B1 and magnesium.
I think its very useful if you use quality forms - MgMalate, MgGlycinate, MgTaurinate. You can also use MgChloride in 1/2L of water if titrated slowly over weeks. Been looking into hemp hearts as well, might experiment with those as they are very high in Mg. Most people are deficient, glyphosate for example depletes Mg in our food. Epsom salt baths are another great way to absorb Mg through the skin.
Magnesium is fundamental to effective vitamin D synthesis and activation.
If you can't get your vitamin D status up, look into magnesium repletion.
Gm NOSTR
You don’t get a sunburn through glass because UVB is blocked, but you still get UVA & HEV-driven oxidative damage and collagen breakdown, without the NIR spectrum that normally signals repair and resilience.
The protective warning of UVB-induced erythema is gone.
Did you know that farm animals living outdoors don't fatten as easily as those living indoors. 🤔
A study done in 1939 showing the effects of UV light on testosterone.
"Exposure of the genital region is more effective than the chest."
People underestimate how powerful this is for gut health.
Which are you?
BTC and “biohackers” are one in the same if you ask me 💡
https://blossom.primal.net/829f7f1ca7faa0d620a872afc1008555f5dc3f804885773f977f0f469548b54e.mp4
Deventeralized Health = Decentralized Wealth
Beach reading
Certain local impairments of enzyme function due to localised heavy metal burden for example can create functional nutrient deficiencies in those organs.
The continual exposure to mismatchedd modern environments is limiting your natural testosterone production and undermining your macsulinity. Male health is faltering and many men are living lives of quiet desperation, wondering why their lust for life has disappeared.
Testosterone levels in men have been declining for decades now. Up to 40% of all tested men are dealing with suboptimal levels of testosterone. That is not normal.
Testosterone and its metabolites not only influences the body's physiology but also shapes a man's mindset and outlook on life. Life fulfillmment is intrinsically tied to proper androgen function. They are bidirectional in nature - as are many things in biology.
There are several reasons why hypogonadism is underdiagnosed.
1. Men hesitate to disclose symptoms of a sexual nature to their doctors due to embarrassment. Moreover, societal conditioning leads them to accept these symptoms as a normal part of aging, dismissing them as unresolvable.
2. Men frequently exhibit vague symptoms like a lack of motivation, depression, and listlessness. Unfortunately, low testosterone is seldom considered as a potential underlying cause for these symptoms.
3. Physicians lack proper awareness regarding hypogonadism and testing is not normalised.
Are you bench maxxing anon?
100%. Couldn't agree more. A lot of unlearning needed to take place, but thats part of the game.
If you are dealing with ANY autoimmune condition, you need to expose yourself to more natural sunlight, especially UV light.
Blessed day.
Something I am grateful to my medical training for is spending an extensive amount of time studying physiology, metabolism & anatomy.
These foundations have been crucial to build on through my own self-guided learning & exploration.
Gm
Never miss a sunrise
Centralized Medicine = Searching for diagnostic label to initiate generalized pharmaceutical treatment pathway.
Top-down, disease-centred framework.
Decentralized Health Optimisation = Detecting & Correcting individual imbalances.
Bottom-up, systems biology-based framework.
Decentralized medicine empowers everybody to take ownership for their own health.
Nobody is coming to save you. You need to make changes to your own life.
Its a beautiful gift, but an even greater responsibility.
Mitochondria lie at the heart of chronic, neolithic disease.
Don't ever forget it. Take care of your colony.
Decentralized Health & Decentralized Wealth
This Is The Way
