Bashing Putin he doesn't dare. But I guess it's no problem to send the national reserve to scare the shit out of LA. Always interesting to know what the military thinks is just. The beginning of the end.
Klinefelter Syndrome
By Marcella Francesca
The Pre-Y Era
Roughly 300 million years ago, mammals developed what we now call the Y chromosome—a relatively small yet influential piece of genetic material responsible for triggering and maintaining male development. But before the Y chromosome existed, life didn’t default to females. Instead, early forms of sexual differentiation were influenced by environmental cues such as temperature, CO2 levels, or population density. Genetic blueprints for male characteristics were distributed across the genome, not concentrated on one specific chromosome. Over time, some of these genetic instructions migrated or duplicated onto what became the Y chromosome.
The Y Patch
While the X chromosome contains between 800 and 1000 genes related to sexual and general development, the Y chromosome only carries around 50 to 60 genes—but they’re potent. The Y chromosome functions like a genetic software patch, fine-tuning or overriding certain X-linked processes to push development in a male direction. It doesn’t act alone, but rather works alongside the X chromosome, altering developmental pathways in favor of male physiology.
The X Patch
In female individuals with two X chromosomes (XX), one X is inactivated early in development—a process called X-inactivation. This prevents overexpression of X-linked genes. In male XY individuals, this inactivation isn’t needed since there is only one X. In people with XXY, however, one of the Xs is not completely inactivated, which can lead to developmental imbalances.
The Making of XXY
XXY arises from a mishap during the formation of sperm or egg cells called nondisjunction. This is when chromosomes fail to separate properly during meiosis. If an egg or sperm ends up with an extra X and combines with a normal partner cell, the result is an XXY zygote. Though often described as a genetic ‘error,’ some view it more as a natural variation—a small evolutionary experiment, albeit one that typically doesn’t get passed on.
How Common Is It?
Klinefelter syndrome occurs in about 1 in 15,000 male births. The extra X chromosome leads to some subtle, and some more pronounced, differences in development. Since X-inactivation isn’t complete, leftover gene activity from the second X can interfere with typical male development and lead to variations in appearance, brain function, and hormone levels.
Developmental Effects
Infancy and Childhood:
Normal birth, but delays in motor skills and language development may appear.
Adolescence:
Puberty may be atypical, with reduced facial and body hair, low muscle mass, and possible breast development (gynecomastia).
Adulthood:
Infertility is common due to impaired testicular function. Testosterone levels tend to be lower, which may affect libido and increase risk for conditions like osteoporosis and metabolic disorders. XXY men are often tall with relatively long legs.
Psychological and Social Aspects
Common traits include social anxiety, emotional immaturity, and difficulty with verbal expression, which can lead to frustration and behavioral challenges.
About 5–15% identify as transgender or non-binary, significantly higher than the <1% observed in XY men.
Approximately 10–20% identify as homosexual or bisexual, also higher than average.
Some XXY individuals experience a stronger connection to femininity, which may be reflected in their clothing, behavior, or gender identity.
Challenges in Diagnosis
Despite having identifiable symptoms, Klinefelter syndrome is often misunderstood or undiagnosed. Symptoms can be mistaken for a "late bloomer," a difficult puberty, or even eccentric adulthood. Only a karyotype test can confirm the diagnosis, and early detection is key for developing a supportive care plan.
Living with XXY
Many XXY individuals lead fulfilling lives—whether in heterosexual, homosexual, or non-binary partnerships. Gender expression and identity are often influenced by the unique interaction between the partially inactive X and the active Y chromosome. Transitioning or identifying as female is not a "chosen" path, but often the natural outcome of how these chromosomes express themselves.
About
By Marcella Francesca
Marcella has Klinefelter syndrome and lives as a transgender woman in a same-sex relationship.
"It’s not that I’m not a man—biologically I am. I have a Y chromosome. The initial genetic setup pointed to a male body. But that extra X—what some call a genetic mistake—pushed my development and identity in a different direction. That sense of womanhood runs deep. It’s stronger than what I imagine most XY men can even conceive. I live in the space between XX and XY."
Oh, great. I just created a new iris.to account and after posting one thing, which was really about nothing, I got three mutes. I follow one person, and it seems that with the default settings, no one can read my posts and I can't read anyone else's either. My first reaction was, ‘Too much total bullocks for a Saturday morning.’ But is that really the case?
In the “Network settings” window of iris.to, I have approximately six network instances. All of them are red. Does this indicate that there is a communication blackout?
