It's the simplest solution for a visual impairment...albeit an expensive one in certain situations xD.

I use screen magnification with 400-600% zoom, and a big screen. Both together give me an easy to see, easy to sit infront of - with normal distance - setup that can also double as a great entertainment corner xD

My wireless keyboard and mouse are on a rollable couch-table. So I can roll the table away and bring my couch closer, and voila; anime/movie corner :D