Is it more difficult? Maybe in one or two contrived cases you set up. On balance across my entire life? I honestly doubt it.
I AM autistic and I CAN see the difference. This is a common neurotypical misunderstanding about autistic people. The issue is that given the autistic brains frame of reference your social rules are irrational, autistic people generally have no respect for irrational rules. There are different social rules that are natural to autistics. From our perspective neurotypicals are rude as fuck and difficult to work with. So who gets to decide which frame of reference should be the one that sets THE rules about manners? I could just as easily say that I have decided all neurotypicals are socially deficient because they can't properly engage with autistic social structures.
I'll point again to all the things built by all the autistic engineers around the world. For example, the entire global telecom system is a constantly growing body proof that autistic social norms enable cooperation that builds amazing things and drives society forward.