it is great to see research focusing on the metabolic cause of alzheimer's. NAD+ issues relate to the mitochondria dysfunction that occurs after years of metabolic dysfunction.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

i think for now the best everyone can do is get their fasting insulin down below 7 and take creatine daily

https://pmc.ncbi.nlm.nih.gov/articles/PMC10594571/