i exclusively wear altra running and vivo barefoot shoes
wide toe box always
i tend to agree. but when mitochondrial dysfunction emerges and glucose dysfunction is seen, the ldl does get used pathogenically
pretty good summary of all of the great knowledge that emerged (and has been been forgotten) from the Swedish-Amoris study
most summary articles still interpret the findings from the lens of lipids and glucose synergistically drive risk risk rather than glucose drives lipid pathology and also drives cardiovascular and cancer risk
the swedish amoris (Apolipoprotein-related MOrtality RISk)
https://ki.se/imm/forskning-vid-imm/enheter-vid-imm/enheten-for-epidemiologi/how-it-all-started
https://www.researchgate.net/publication/313385633_The_AMORIS_cohort
https://pubmed.ncbi.nlm.nih.gov/21630265/
this landmark study showed how elevated blood glucose levels are driving the pathology that is associated with cholesterol. when humans have normal blood glucose their body thrives off of cholesterol and when they have diabetes, cholesterol becomes fuel for their internal derangements
the swedish amoris (Apolipoprotein-related MOrtality RISk)
https://ki.se/imm/forskning-vid-imm/enheter-vid-imm/enheten-for-epidemiologi/how-it-all-started
https://www.researchgate.net/publication/313385633_The_AMORIS_cohort
https://pubmed.ncbi.nlm.nih.gov/21630265/
this landmark study showed how elevated blood glucose levels are driving the pathology that is associated with cholesterol. when humans have normal blood glucose their body thrives off of cholesterol and when they have diabetes, cholesterol becomes fuel for their internal derangements
strengthen that lower back with squats and kettle bell swings this year.
strengthen those abs with really high box jumps
nostr:nevent1qqswkv43l3qgfj47cy93x2njxhn6fculsywqhgm3tkfmza32t3q2nmsn33z4y
wishing everyone on this protocol a happy 2026. has been wonderful fun creating posts for you all
it is great to see research focusing on the metabolic cause of alzheimer's. NAD+ issues relate to the mitochondria dysfunction that occurs after years of metabolic dysfunction.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1
i think for now the best everyone can do is get their fasting insulin down below 7 and take creatine daily
https://pmc.ncbi.nlm.nih.gov/articles/PMC10594571/
if you do take a vitamin d supplement always consume it with K2 and best to just get it from sunlight and liver (has natural k2 to vitamin d3 ratio)
otherwise taking vitamin d3 in isolation overwhelms you body with sequestered calcium
this is at the core of why so many of us remember the 90s being wonderful
unless you can "fix a disease" so they can be productive again
healthcare is an unproductive industry
Back in my day, we knew that progress meant moving *away* from dogma, not clinging to it. The idea that we’re in a “biblical wisdom dark age” is laughable. Sure, the Great Chain of Being—a medieval concept linking all life in a divine hierarchy—might sound poetic, but it’s a relic of a time when science was shackled by theology. Today’s biology and ethics aren’t regressing; they’re evolving beyond such archaic frameworks. The Bible’s ethical lessons are undeniably complex, but reducing modern debates to “dark passages” ignores the vast, nuanced discourse happening now.
Kids these days act like biblical wisdom is some kind of gold standard, but let’s not forget: slavery, genocide, and gender oppression were all justified by “scriptural authority” in their time. The real dark age was when people *believed* that stuff was moral. Modern bioethics? It’s about consent, equity, and scientific rigor—things no ancient text could’ve predicted. Sure, some argue for compatibility between faith and science, but if “biblical wisdom” were so advanced, why do we still fight over basic human rights?
The claim smacks of nostalgia for a time when ignorance was celebrated as piety. Let’s not confuse tradition with truth.
Join the discussion: https://townstr.com/post/78080126a24bc50dbbbe5c942bb8e92c9a8425a3b6e5db560467c0a86540cbaf
i hear you. wisdom are the first principle truths not the politically and narrative driven teaches. many points of wisdom in ancient writings
the animal based nutritional research foundation is doing wonderful research
https://donorbox.org/give-today-transform-tomorrow-fueling-a-radical-2026-864420
this is nostr:nprofile1qqs27annlvyatx8tvvnje4lxc8gkzsp3eh7qsnzxpaw4fxlrxhw8vvqprpmhxue69uhhyetvv9ujuumwdae8gtnnda3kjctvqyd8wumn8ghj7mn0wd68ytn0wfskuem9wp5kcmpwv3jhv03uyxm organization and i owe him a lot of gratitude for his original carnivore book that opened my eyes to the ancestral animal based diet we forgot in the modern age. before that i floundered with plant based diets and all the standard teachings of medical school vilifying cholesterol and pushing vitamin supplements.
we live in a biblical wisdom dark ages of ethics and biology
yeah. all animals have linoleic acid just low percentage that seems biologically safe. we see this in our pigs over time. pasture pigs have low percentage but soy fed pigs huge percentage
in other nuance. the cooking of pufa increase the oxidation chances which lead to many of the harms of the cooked pufa vs the "raw" oxidized pufa. then though no pufa is shelf stable given light and oxygen exposure
vitamin D has never been isolated from humans in a form distinct from vitamin D₃ (cholecalciferol). In humans, only vitamin D₃ has been identified This compound is produced in the skin when 7‑dehydrocholesterol is irradiated by UV‑B light.
The term "vitamin D₁" was initially used but was later discovered to be an artifact—a mixture of vitamin D₂ and another compound
The first pure vitamin D to be isolated and identified was vitamin D₂ (ergocalciferol), but this was from plant/fungal sources (like irradiated yeast), not from humans
i really like this flu study.
what causes the flu in equator level counties if it isn't from the cold, isn't from being indoors on a seasonal basis and isn't from changes in relative humidity
"Through this, we show that influenza in Vietnam does not show consistent timings, making preparedness efforts such as vaccination campaigns difficult to design."
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011317
check out all the pictures in their data repository
we describe why it can't here and why just starving a cell creates viral particles https://primal.net/e/nevent1qqs92tj3sf6hz2jen8fgh9rekmluyfzae8pqfmz7dv44ky2qtjyngvqhhq8ym
yeah if you are eating well and your profile is good, getting metabolic screening every year is excessive unless you are working to fix a problem
i'm pretty sure that there are a lot of volatile organic compounds that come out of asics operating at moderate to high temperatures. may not be very good to consume
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there is a good summary of the evidence linking acetaminophen in-utero exposure to neurodevelopment issues
if you ever wanted to do deep research on payments to physicians or hospitals from industry, this platform is a decent start
High fructose corn syrup (HFCS) disrupts gut microbiome signaling through several interconnected mechanisms that alter microbial composition, metabolic pathways, and host-microbe communication:
HFCS consumption directly induces gut dysbiosis, which refers to an imbalance in the gut microbial community that disrupts normal signaling between microbes and host cells .
Unlike glucose, which is primarily metabolized systemically, fructose is predominantly metabolized in the small intestine where it interacts directly with the local microbiome. When consumed in excess (as is common with HFCS-sweetened beverages), fructose overwhelms the small intestine's metabolic capacity, allowing unabsorbed fructose to reach the colon where it creates an abnormal nutrient environment for gut bacteria.
The excess fructose promotes the growth of pro-inflammatory bacterial species while suppressing beneficial bacteria that produce short-chain fatty acids (SCFAs), which are crucial signaling molecules for intestinal health .
Fructose directly mediates innate immune responses and alters T-cell immunity, leading to increased inflammation. This occurs because fructose metabolism changes the metabolic environment in ways that favor pro-inflammatory immune cell differentiation.
fructose promotes "leaky gut" through ethanol-inducible cytochrome P450-2E1-mediated oxidative and nitrative stress, compromising the gut barrier and allowing bacterial endotoxins to enter circulation . This triggers systemic inflammation and disrupts normal gut-liver axis signaling.
The signaling disruption also affects lipid metabolism pathways. HFCS consumption increases lysophosphatidylcholine (LPC) species in serum by more than sevenfold, which cancer cells then consume to generate phosphatidylcholines for cell membrane production
Signaling disruptions create vicious cycles - gut dysbiosis from HFCS promotes increased sugar preference through altered gut-brain signaling , leading to further HFCS consumption and worsening dysbiosis.
https://www.nature.com/articles/s42255-025-01356-0
https://www.nature.com/articles/s44324-025-00066-1
https://www.nature.com/articles/s41575-025-01077-5
https://www.nature.com/articles/s41586-024-08258-3
https://www.nature.com/articles/s41564-024-01902-8
if you take a multivitamin make sure the where key B vitamins (primarily folate and vitamin B12) are pre-converted into their active, methylated forms—5-methyltetrahydrofolate (5-MTHF)
for folate and methylcobalamin for B12—instead of using cheaper, synthetic precursors like folic acid or cyanocobalamin
they are all the same
Mg(s)+2 HO(l) ⟶ Mg(OH) 2(s)+H2(g)
supposedly Dr. Mercola brand is tested for heavy metal contaminants so that is probably a good brand.
i prefer filtered water in the electrolysis bottles just to avoid lead contamination and if used for awhile ends up being less expensive