It’s possible that as much as 20% of all bitcoin is irrecoverably lost.
"Lost coins only make everyone else's coins worth slightly more. Think of it as a donation to everyone."
- Satoshi Nakamoto
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That’s not really true though.
It's a fun quote though, lol. Market price is always at the margin, but lost coins does reduce the available supply. It's not an issue right now since there's plenty of supply on exchanges for people to buy.